Paraptosis is a programmed cell death characterized by cytoplasmic vacuolation, which has been explored as an alternative method for cancer treatment and is associated with cancer resistance. However, the mechanisms underlying the progression of paraptos
Inhibition of Sirt1 by its inhibitor, Tenovin-6 blocked the shuttling and impacts the sensitivity of PDAC to therapeutics [159]. In addition, SIRT1 promotes EMT ability and invasion of pancreatic cancer cells by forming a complex with twist-related protein 1 (TWIST1) and methyl-CpG binding ...
12. The method of claim 1, wherein the cancer is recurrent or progressive after a therapy selected from surgery, chemotherapy, radiation therapy, or a combination thereof. 13. The method of claim 1, wherein the anti-CSF1R antibody blocks binding of CSF1 and/or IL-34 to CSF1R. 14. The...
In the context of a multiple dependent claim, the use of “or” refers back to more than one preceding independent or dependent claim in the alternative only. Also, terms such as “element” or “component” encompass both elements and components comprising one unit and elements and components...