Studies favor the use of resistant alleles that can still encode for functional translational initiation factors over loss-of-function alleles, which lead to a narrower resistance spectrum [[144], [145], [146]]. Achieving multiple amino acid changes using DSB-dependent genome editing tools and ...
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S. MagnEdit—interacting factors that recruit DNA-editing enzymes to single base targets. Life Sci. Alliance 3, e201900606 (2020). PubMed PubMed Central Google Scholar Yu, Y. et al. Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity. ...
Discussions with respect to MRD assessment in AML often seem polarized, with questions raised as to whether the information provided (1) adds anything to what is already known about a patient’s prognosis based on conventional risk factors, increasingly complemented by molecular profiling data; and ...
To estimate the possible formation conditions of mineral assemblages and the role of various factors affecting the mineral composition (host rocks and magmatic input), we simulated the process of crystallization of mineral assemblages of Zn-rich sulfides of the Irinovskoe HSF by Gibbs energy minimizat...