mRNA secondary structure at start AUG codon is a key limiting factor for human protein expression in Escherichia coli. Biochem. Biophys. Res. Commun. 349, 69–78 (2006). Article CAS PubMed Google Scholar Li, Y., Luo, L., Thomas, D. Y. & Kang, C. Y. The HIV-1 Env protein ...
We chose the p53 transcription factor as a prototype to test this approach for investigating the biological impact of specific genetic variants. Notably, TP53 is the most frequently mutated gene in cancer and exhibits extensive allelic variation, leading to the generation of altered proteins that can...
What is the set of numbers between 2 and 30, without the same common factor (e.g. 26 and 24 shares 2, so they cannot be in the same set) that would give a maximum sum? Find the cardinal number for the following sets: A = {112, 113, 114, 115, ..., 171} B = {11...
The goal of this study was to create a dominant-negative (DN) vascular endothelial growth factor receptor (VEGFR) 2 by editing genomic DNA with an advanced PE system to block aberrant retinal angiogenesis in a mouse model of oxygen-induced retinopathy. Methods An advanced PE system (referred to...
Cytokine Growth Factor Rev. 2020, 56, 4–27. [Google Scholar] [CrossRef] Kramer, M.; Dennin, R.; Kramer, C.; Jones, G.; Connell, E.; Rolon, N.; Gruarin, A.; Kale, R.; Trown, P. Cell and virus sensitivity studies with recombinant human alpha interferons. J. Interf. Res....
The myostatin (MSTN) gene, known as growth differentiation factor-8 (GDF-8), is a member of the transforming growth factor-β (TGF-β) superfamily and plays a specific inhibitory role during the critical phases of skeletal muscle mass development in vertebrates. This study was conducted to inv...
Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy. J. Allergy Clin. Immunol. 2018, 141, 991–1001. [CrossRef] [PubMed] 96. Ashley, S.E.; Tan, H.T.; ...
Another study (87) examined the effect of risk factor modification on arterial FDG uptake. After 17 months, there was a 65% reduction in the number of vascular regions that accumulated FDG. Again, the magnitude of the reduction closely paralleled the increase in high-density lipoprotein seen in...
It is recognized as one of the most prestigious journals in the field. With an impact factor of 6.825*, mt ranks in the top 4.2% of scientific journals in the latest Science Citation Index. Published monthly online and in print.doi:10.1016/j.ymthe.2005.07.676TANG, Y...
of human insulin-like growth factor for cubital tunnel syndrome 1 Ocular Retinitis pigmentosa 3 Other Erectile dysfunction, type I diabetes mellitus and overactive bladder syndrome Phase II 10 Cancer Melanoma, angioendothelioma, squamous cell carcinoma of the head and neck, lung cancer, mantle cell...