DNA primase is a DNA-dependent RNA polymerase that synthesizes the first ~10 nucleotides and then transfers the substrate to polymerase α to complete primer synthesis. From: Methods in Enzymology, 2017 About this pageSet alert Also in subject areas: Neuroscience Nursing and Health Professions Pharm...
noun (biochemistry) An RNA polymerase involved in the initiation of DNA synthesis 更多 primase 的语法和变格 primase ( plural primases) 更多 例句与“ primase " 变形 干 This primase is structurally similar to many viral RNA-dependent RNA polymerases, reverse transcriptases, cyclic nucleotide ...
Crystal structure of a DNA-dependent RNA polymerase (DNA primase). Nat Struct Biol. 2001; 8 :57–61.Augustin, M. A., Huber, R. & Kaiser, J. T. Crystal structure of a DNA- dependent RNA polymerase (DNA primase). Nat. Struct. Biol. 8, 57-61 (2001)....
DNA replication is heavily dependent on several enzymes to progress. An example of these enzymes is DNA polymerase. DNA polymerase is found in both eukaryotes and prokaryotes and is a highly conserved structure. This means that the active site of this enzyme, which is where it processes the ...
T7 primase, which can synthesize RNA primers, is located in the N-terminal half of the multifunctional gene 4 helicase-primase protein13. The primase domain is composed of an RNA polymerase domain (RPD) and a zinc-binding domain (ZBD). The two domains are connected by an unstructured ...
Pol-prim is comprised of two different polymerases,primaseand pol α, whose activities are distinct but tightly coordinated. Primase is a DNA dependent RNA polymerase that initiates daughter strand synthesis by generating the initial primer of 7–12 ribonucleotides (NTPs). This initial RNA primer ...
DNA replication in almost all organisms depends on the activity of DNA primase, a DNA-dependent RNA polymerase that synthesizes short RNA primers of defined size for DNA polymerases. Eukaryotic and archaeal primases are heterodimers consisting of small catalytic and large accessory subunits, both of...
Biochemistry, University of Bayreuth, Universita¨ tstrasse 30, 95447 Bayreuth, Germany Received July 4, 2007; Revised and Accepted July 30, 2007 ABSTRACT Primases are specialized DNA-dependent RNA poly- merases that synthesize a short oligoribonucleotide complementary to single...
Further, gp577 extends a DNA/RNA primer annealed to a DNA or RNA template using deoxyribonucleoties (dNTPs) or ribonucleotides (NTPs) demonstrating its DNA/RNA polymerase and reverse transcriptase activity. We also show that gp577 possesses terminal transferase activity and is capable of ...
近日,来自美国洛克菲勒大学的Titia de Lange和Joseph T. P. Yeeles研究团队在Nature上发表题为CST–polymerase α-primase solves a second telomere end-replication problem的文章,发现第二个末端复制问题,在体外重构的DNA复制系统中,后随链DNA复制...