Role of protein in the primary step of the photoreaction of yellow protein. Proteins 2004, 55, 1063-1069.A.Yamada,T. Ishikura,T. Yamato.Role of protein in the primary step of the photoreaction of yellow protein. Proteins: Structure, Function and Bioinformatics . 2004...
We explored the role of Gi protein signaling in the regulation of interleukin (IL)-12 production and T helper cell type 1 (Th1) T cell differentiation. In initial studies, we showed that treatment of normal mice with pertussis toxin (PT), which inhibits Gi protein signaling, enhanced the ...
To examine the role of the protein environment on the chromophore photoconversion dynamics, we selected a series of red FPs with the same chromo- phore, including DsRed2, its monomeric offspring mFruits, and several new chimeras (see Methods). The photobleaching kinetics of the proteins, ...
(2002). Role of protein kinase C alpha in primary human osteoblast proliferation. J Bone Miner Res, 17 , 1968–1976. View ArticleLampasso JD, Marzec N, Margarone J, III, Dziak R. 2002. Role of protein kinase C a in primary human osteoblast proliferation. J Bone Miner Res 17:1968-...
Although both APS and CAP (c-Cbl-associated protein) interact with c-Cbl during insulin signaling, the relative importance of each protein in recruiting c-Cbl has not been clear. We performed a side-by-side comparison by ectopic expression of APS or Src homology 2-Bα (SH2-Bα) and ...
Modestly powered genome-wide association studies (GWAS)5,6,7,8,9,10 have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility11. Most of the genetic architecture underlying ...
To investigate whether the Epac-Rap-RapGAP pathway could play a potential role in thyroid tumorigenesis, the mRNA expressions of its constituent proteins were investigated in two malignant thyroid tumor types. Modulations of this pathway suggest an increased Rap pathway activity in these cancers ...
Amyloid β-protein (Aβ) is linked to neuronal injury and death in Alzheimer's disease (AD). Of particular relevance for elucidating the role of Aβ in AD ... G Bitan,MD Kirkitadze,A Lomakin,... - 《Proceedings of the National Academy of Sciences of the United States of America》 ...
Given the role of AMPK in regulating glucose metabolism and our data indicating that AMPK is hyperactivated in TAZ-KO cells, we sought to test whether TAZ-KO cells also exhibit altered glucose homeostasis, as reported in BTHS patients1,31. Previous studies have shown that pharmacological activati...
Thus, regulatory B cells (Bregs) play a critical role in the disease. Indeed, anti-drug antibodies that emerge in the late stages of the disease appear to be responsible for the incomplete depletion of hCD20+ B cells [29]. Although PBC targets cholangiocytes, the cells are safeguarded ...