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(HLA) locus and identified 27 non-HLA risk loci2,3,4,5,6,7,8. Consistent with GWAS data for other autoimmune diseases, results of these studies implicate immune-related genes in disease pathogenesis, but in general fail to pinpoint the disease-causal variants within the identified risk loci...
Critical point drying was then performed and samples mounted on aluminum stubs before overnight vacuum drying. They were then gold coated and imaged with a Jeol JSM-35CF scanning electron microscope (Jeol, Welwyn Garden City, UK). Statistics Galectin-3 signals were standardized against β-actin ...
Thus, despite the presence of many candidate variants with regulatory or epigenetic roles within PBC risk loci, more direct biological experimental approaches are required to pinpoint the disease-causal variants at these loci. We also applied functional GWAS (FGWAS) and its associated annotation file...