However, biological heterogeneity as well as drastic alterations in growth factor-signaling, cell鈥揷ell adhesion, gene expression, motility or cell shape of disseminated cancer cells in contrast to cancer cells of the primary neoplasm supports escape mechanisms for metastases to overcome conventional ...
On the basis of the present cases and a review of 15 reports from the literature, primary MMMT of the female peritoneum proved to be a rare but highly malignant neoplasm occurring in elderly postmenopausal women. Of 15 patients with available follow-up, 12 died with disease, mostly within 1...
Somatic BAP1 mutations are predominantly present in UMs with monosomy 3 (~85 %), the latter being a strong predictor for metastatic disease [9, 10, 12]. In this setting BAP1 functions as a tumor suppressor gene, with loss of one copy of chromosome 3 and mutation in the other BAP1 ...
In this section, we discuss the use of both, primary cells and cell lines, to study disease mechanisms and therapy developments for AMD, DR, or glaucoma. 3.1 Cell lines: convenience and ease versus complexity and diversity As with many fields of research, ophthalmic researchers commonly work ...
关键词: Laparoscopic liver resection Elderly patients Liver neoplasm Hepatectomy Hepatocellular carcinoma and liver metastases 年份: 2013 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 掌桥科研 ResearchGate (全网免费下载) 相似文献 参考文献Laparoscopic...
Discussion: The presence of a renal mass diagnosed on a CT scan in a patient with lung cancer is not always synonymous with metastatic disease. Confirmation of diagnosis by tissue sampling is mandatory, especially if a synchronous primary tumor is possible. Related...
407 patients with cancer of unknown primary (CUP) or metastatic malignant disease of unknown primary origin (MUO) were referred to the Aichi Cancer Center Hospital (ACCH). †Patient`s characteristics; male 59%, median age 65 years, range: 29–91 years, and eight patients were referred for...
Entities that cause bile duct damage but that prob- ably do not lead to biliary cirrhosis include graft- versus-host disease and hepatitis C. DIAGNOSTIC PROBLEMS: HEPATITIS Case 4 An 80-year-old man with clinical liver failure, status-post diagnosis of prostatic adenocarcinoma (Gleason score 8,...
However, there is no case of symptoms of metastatic urinary tract SRCC appearing earlier than those of primary tumors and there is only one case of melanoma where symptoms of ureteral metastasis preceded the recognition of the primary neoplasm [33]. As we are writing, more than one year has...
we found a significant upregulation of p27 at the highest dose (10 nM); such an increase was due to plitidepsin acting at the transcriptional level since the amount of p27 mRNA measured by real-time quantitative PCR increased significantly in all myeloproliferative neoplasm-derived cells exposed...