Karen, Canfell,Marion,etc.Protocol for Compass: a randomised controlled trial of primary HPV testing versus cytology screening for cervical cancer in HPV-unvaccinated and vaccinated women aged 25-69 years living in Australia.[J].2018,8(1)....
This randomized clinical trial compares the effects of cervical HPV vs cytology (Pap smear) screening on the cumulative incidence of high-grade cervical
but who test negative for HPV. This is an argument for cotesting, because some of these lesions would be picked up by cytology. However, patients with precancerous lesions detected on cotesting by abnormal cytology but negative HPV tests make up a very small fraction of all patients with pr...
The screening interval for women with a negative HPV test is 5 years, compared to 3 years with cytology, and endeavors to minimize false negative results is particularly important. An evaluation of the inter-laboratory reproducibility of the HPV testing was initiated as part of the quality ...
HPV self-sampling has demonstrated similar clinical accuracy as HPV testing on clinician-collected samples [5, 6]. However, cytology triage currently requires recalling women who are HPV-positive on a self-collected sample for clinician-based sampling. Emerging evidence has demonstrated that the ...
From 2015, Norway has implemented high‐risk human papilloma virus (hrHPV) testing in primary screening for cervical cancer. Women aged 34–69 years, living in four counties, have been pseudo‐randomly assigned (1:1 randomization) to either hrHPV testing every 5 years (followed by cytology if...
Ogilvie, G. S., van Niekerk, D., Krajden, M., Smith, L. W., Cook, D., Gondara, L. et al. Effect of screening with primary cervical HPV testing vs cytology testing on high-grade cervical intraepithelial neoplasia at 48 months: the HPV FOCAL randomized clinical trial.JAMA320, 43–...
In England, bivalent vaccination (Cervarix) against high-risk human papillomavirus (HR-HPV) genotypes 16/18 was offered in a population-based catch-up campaign in 2008–2010 to girls aged 14–17 years. These women are now entering the national cervical s
Fourth, issues regarding HPV-negative cancers and the implications for the relative effectiveness of hrHPV testing alone vs cytology alone or cotesting were not fully addressed.27 The sensitivity analysis in which hrHPV relative test sensitivity (compared with cytology) was decreased to a lower bound...
HPV detection and typing The quality of DNA samples was analysed using aβ-globin real-time PCR using 1 μl of the sample. All samples that we included for future analysis wereβ-globin positive. Human papillomavirus testing was performed by PCR amplification of a fragment in the L1 gene....