aNucleotides serve a diverse set of important functions in cells. As subunits of nucleic acids they carry genetic information. They are also the primary carriers of chemical energy in cells, structural components of many enzyme cofactors, and cellular second messengers. 核苷酸在细胞供应不同的套重要...
1988. Sequence comparison with concave weighting functions. Bull. Math. Biol. 50, 97-120. Roytberg M.A. 1988. Fast algorithm for optimal aligning of symbol sequences. Teoreticheskie issledovaniya i banki dannykh v molekulyarnoi biologii i genetike (Theoretical studies and databases in ...
These cells are heterogeneous and highly plastic as they differentiate and acquire distinct functions to counter pathogens and navigate changing environments [42]. Fine-mapping of GWAS loci, expression quantitative trait loci (eQTLs), and epigenomic studies have shown that immune disease-associated risk...
IgG3 antibodies are particularly effective in the induction of effector functions. Being a potent proinflammatory antibody, its shorter half-life may function to limit the potential of excessive inflammatory responses. However, the finding that some individuals bearing the sG3m allotypic marker also hav...
(TZ). Ciliary subcompartment located between the basal body and cilium itself, which functions as a barrier for selective transport of molecules into and out of the cilium. Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this...
The transmembrane proteins SLC35A4, uORF, and TRABD, which were highly uncharacterized proteins without clear knowledge of functions in the database, might be potentially intriguing targets for further investigation. Additionally, we also identified TMEM160 in our analysis, and initially categorized ...
However, outside of mitosis, the mother centriole (the centriole that was inherited during cell division as opposed to the one that is formed after division is complete) becomes the basal body of the primary cilium. As such, it functions as both an anchor for the primary cilium and a ...
(D) Distribution of signature genes on the chromosome cytobands. Full size image In contrast, the principal functions of the p-regulated genes in the NGMGCT group (IPG/PPG) of pediatric GCTs include those related to small GTPase (Rho protein especially) mediated signal transduction (Figure 3B...
In mouse pancreatic cancer, this is accommodated by the downregulation of protein synthesis, one of this tissue’s major energy costs. We propose that, as solid tumours develop, cancer cells shed energetically expensive tissue-specific functions, enabling uncontrolled growth despite a limited ability ...
Several pathways are particularly central to immunologic functions and are shared among a number of cellular processes. Understanding these pathways can serve as a foundational approach to considering the immune deficiencies impacted by these pathways and can also provide insights to new genes discovered ...