Primary biliary cholangitis (PBC) is an autoimmune liver disorder characterized by progressive destruction of intrahepatic bile ducts, leading to cholestasis, cirrhosis, and liver failure. The etiology of PBC is unknown; however a complex interaction between genetic, environmental, and autoimmune factors ...
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[摘要] 目的 筛选原发性胆汁性胆管炎(PBC)患者无创肝硬化诊断敏感指标。方法 收集2011—2020年在首都医科大学附属北京佑安医院住院确诊为PBC的患者380例。常规电子胃镜、血常规、凝血、肝功能及B超检查,瞬时弹性扫描仪(FibroScan)测定肝脏硬度,根据肝穿及临床诊
Recommendation 1: The presence of isolated AMA positivity with normal serum liver tests is not sufficient to make the diagnosis of primary biliary cholangitis. However, in consideration of the potential for disease progression, these patients should be monitored on an annual basis with liver biochemist...
We describe the first well documented patient with an overlap between the three autoimmune liver diseases, primary biliary cholangitis, autoimmune hepatitis and primary sclerosing cholangitis. The rare overlap between PBC and PSC has been reported in only 11 patients in the literature to date [[5],...
Anti-mitochondrial antibody (AMA) is not always present in patients with primary biliary cholangitis (PBC). We aimed to determine the additional value of anti-hexokinase 1 (anti-HK1) and anti-kelch-like 12 (anti-KLHL12) antibody in PBC and analyzed the biochemical and immunological parameters ...
Primary biliary cholangitis (PBC) is a chronic and cholestatic liver disease characterized by an autoimmune-mediated destruction of intrahepatic bile ducts. E26 transformation specific sequence 1 (ETS-1) is a transcription factor regulating the expression of various immune-related genes. The aim of our...
Primary biliary cirrhosis occurs more frequently in women, and previous studies indicated that the average age of primary biliary cirrhosis (PBC) onset mak
Chemokine ligand 20 (CCL20) and its chemokine receptor CCR6 contribute to the formation and function of mucosal lymphoid tissues and are notably, in the context of the immune-mediated lymphocytic cholangitis char- acteristic of PBC, involved in the localization of Th17 cells and CD8 effector T...
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by persistent, progressive biliary inflammation, fibrosis and eventually end-stage liver disease. Clinical manifestations and progression of the disease are heterogeneous. No reliable biomarkers have been identified to th...