Promising clinical investigations are underway to alleviate these symptoms. Efforts to facilitate better access to medical care and dissemination of current knowledge should enable diagnosis at an earlier stage of primary biliary cholangitis and ensure access to treatments based on risk stratification for ...
Heritability Estimation from Summary Statistics; IBD, inflammatory bowel disease; (S)LDSC, (stratified) linkage disequilibrium score regression; MAGMA, multi-trait analysis of GWAS; PBC, primary biliary cholangitis; scRNAseq, single cell RNA sequencing; SMR, summary statistics-based Mendelian randomizatio...
: Therapeutic investigations in primary sclerosing cholangitis . Dig Dis Sci 1986, 31 :792–798.Grijm R, Huibregtse K, Bartelsman J, Mathus-Vliegen EM, Dekker W, Tytgat GN. Therapeutic investigations in primary sclerosing cholangitis. Dig Dis Sci 1986;31:792-798....
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease associated with profound metabolic changes. The purpose of this study was to identify a distinctive metabolic signature from the training set with 29 PBC patients, 30 hepatitis B virus (HBV)-caused cirrhosis (HBC) and 41 heal...
Recommendation 1: The presence of isolated AMA positivity with normal serum liver tests is not sufficient to make the diagnosis of primary biliary cholangitis. However, in consideration of the potential for disease progression, these patients should be monitored on an annual basis with liver biochemist...
The presence of the symptoms , particularly in a patient known to have inflammatory bowel disease, should raise the suspicion of primary sclerosing cholangitis. Various investigations are therefore required to confirm the diagnosis. Tests to assess liver function should also be conducted as the liver ...
Ulcerative colitis, autoimmune hemolytic anemia and primary sclerosing cholangitis in a child A 15-month-old female who initially presented with autoimmune hemolytic anemia (AIHA) is described. She developed bloody stools and was diagnosed with ulcerative colitis (UC). Investigations of persistent hepato...
Primary sclerosing cholangitis (PSC) is a chronic bile duct disease leading to fibrotic biliary strictures and liver cirrhosis. The patient population is heterogeneous with regard to disease progression and the presence of co-morbidities, complicating the practical handling of patients as well as studies...
The relationship between primary biliary cholangitis (PBC), a chronic cholestatic autoimmune liver disease, and the peripheral immune system remains to be fully understood. Herein, we performed the first mass cytometry (CyTOF)-based, immunophenotyping analysis of the peripheral immune system in PBC at...
Primary biliary cholangitis Breg: Regulatory B cells AMA: Antimitochondrial antibody Tim-1: T cell immunoglobulin mucin domain-1 PBMC: Peripheral blood mononuclear cells TLR: Toll-like receptor BCR: B cell receptor HC: Healthy control ALT: Alanine aminotransferase AST: Asp...