gasseriLA39 activates the hepatic primary BA biosynthesis and promotes the intestinal secondary BA biotransformation. Based on these findings, we suggest thatL. gasseriLA39 confers an important function in the gut鈥搇iver axis through regulating BA metabolism.Jun Hu...
In man, hepatic mitochondrial sterol 27-hydroxylase and microsomal cholesterol 7α-hydroxylase initiate distinct pathways of bile acid biosynthesis from cholesterol, the "acidic" and "neutral" pathways, respectively. A similar acidic pathway in the rat has been hypothesized, but its quantitative importan...
Regulation of sterol 27-hydroxylase and an alternative pathway of bile acidStravitz RT, Vlahcevic ZR, Russell TL, Heizer ML, Avadhani NG, and Hylemon PB. Regulation of sterol 27- hydroxylase and an alternative pathway of bile acid biosynthesis in primary cultures of rat hepatocytes. J ...
62: Increased degradation of cholesterol via the alternate pathway of bile acid biosynthesis in primary hypercholesterolemiadoi:10.1016/j.jacl.2008.08.064NoneELSEVIERJournal of Clinical Lipidology