We also determined the stability of the models at both the epigenetic and genetic level. For the former we measured methylation profiles of 15 PDX/PPC pairs and used 8 common RMS cell lines (4 ARMS and 4 ERMS) as comparison. Principle component analysis (PCA) revealed that in 13 out of ...
times. Combinatorial definition of PyNPlxnD1subtypes by lineage, birth time and anatomical location achieved byTbr2;PlxnD1intersection: tamoxifen at E13.5 and at E17.5 labelled differentTbr2-expressing IP-derived PyNPlxnD1cohorts. Boxed areas in MOp (top row) are shown in the bottom row.f–i,...