Metastatic colorectal cancer (CRC) is still in need of effective treatments. This study applies a holistic approach to propose new targets for treatment of primary and liver metastatic CRC and investigates their therapeutic potential in-vitro. An integra
Sensitivity analyses with redefined Current-H (Online Supplement 3), further stratification by CRT-D or ICD device type (Online Supplement 4), and propensity score–matched analyses (Figure 4B and Online Supplement 5) did not substantially differ from the main analyses. Discussion In this study of...
ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; CCI, Charlson Comorbidity Index; CDR, Cardiac Device Registry [Cardiac Services BC]; HEARTis, Heart Information System [Cardiac Services BC]; HIV, human immunodeficiency virus; MRA, mineralocorticoid receptor antagonist; Q...
Gardenia jasminoidesJ. Ellis with the main constituents iridoid glycosides and crocins prolonged bleeding time and inhibited platelet aggregation and thrombosis in rats [110]. Another study revealed that geniposide, one of the constituents ofG. jasminoides, exerted antithrombotic activity in mice. Genipos...
The main goals of ITP treatment are to prevent bleeding and maintain the platelet count above a safe level to minimize the bleeding tendency. Notably, the safe lower limits for platelet counts vary among patients and are related to individualized bleeding risks. The updated ASH guidelines recommend...
(vehicle): the same treatment, but without antagonist.C-DWT ciliated neurons (n = 99) reach differentiation stage 3 more efficiently than non-ciliated neurons (n = 91) in the control experiment (vehicle), while no difference was observed between ciliated (n = 129) and non-...
Main During meiosis, homologous chromosomes (homologues) undergo meiotic recombination, exchanging genomic material between them. This exchange is initiated by physiologically induced DNA double-strand breaks (DSBs)1,2. The formation of meiotic DSBs is commonly resolved via crossovers (COs) or other ...
SSTR2 involvement was assessed by using the specific antagonist CYN 154806. No differences were observed between frequency increase in CAP alone vs. CAP in the presence of CYN 154806+OCT. The effect of OCT was further investigated by studying c-fos expression in spinal cord slices. The CAP-...
For example, somatosensory cortical responses in cats can be suppressed by sound or by electrical activation of the auditory anterior ectosylvian sulcal field and this crossmodal modulation is blocked by local application of a GABA receptor antagonist45. Furthermore, in mice, optogenetic stimulation ...
Receptors involved in AEA-mediated enhancement of efferocytosis in MoDMs. Selective antagonist are used to specifically target CB2, TRPV1, PPARγ, and GPR18 (A). Effect of the selective blocking of AEA-binding receptors on efferocytosis of pHrodo red-labeled HL-60 apoptotic cells (B), with...