Introduction Primary adrenal insufficiency (AI) is a rare endocrine disorder affecting 1 in 100,000 people. Primary AI is a gradual destruction of the adrenal cortex. Etiology includes autoimmune, tuberculosis, histoplasmosis, blastomycosis, adrenal metastases, primary adrenal tumors, and opportunistic inf...
We will then look at the autoimmune mechanisms underlying autoimmune adrenal insufficiency and how autoantibodies are important for diagnosis. We end with a discussion on how to move the field forward emphasizing on the clinical workup, early identification, and potential targeted ...
A. et al. Adrenal insufficiency after unilateral adrenalectomy in primary aldosteronism: long-term outcome and clinical impact. J. Clin. Endocrinol. Metab. 104, 5658–5664 (2019). PubMed Google Scholar Fassnacht, M. et al. Management of adrenal incidentalomas: European Society of Endocrinology...
In such cases, consider repeating infectious workup to exclude alternative etiologies. Immune-Mediated Hepatitis JEMPERLI can cause immune-mediated hepatitis, which can be fatal. Grade 3 hepatitis occurred in 0.5% (3/605) of patients. Immune-Mediated Endocrinopathies Adrenal Insufficiency Adrenal ...
Adrenal insufficiency led to permanent discontinuation of KEYTRUDA in <0.1% (1) and withholding in 0.3% (8) of patients. All patients who were withheld reinitiated KEYTRUDA after symptom improvement. Hypophysitis KEYTRUDA can cause...
In KEYNOTE-564, when KEYTRUDA was administered as a single agent for the adjuvant treatment of renal cell carcinoma, serious adverse reactions occurred in 20% of patients receiving KEYTRUDA; the serious ad...
In KEYNOTE-564, when KEYTRUDA was administered as a single agent for the adjuvant treatment of renal cell carcinoma, serious adverse reactions occurred in 20% of patients receiving KEYTRUDA; the serious adverse reactions (≥1%) were acute kidney injury, adrenal insufficiency, pneumonia, colitis, an...
48 The two most common endocrine irAEs are acute hypophysitis with secondary adrenal insufficiency (0.1%-6.4%) and thyroid dysfunction (hypothyroidism [3.8%-13.2%]; hyperthyroidism [0.6%-8%]; thyroiditis [1.6%-4.6%]).49,50 Other rare endocrine irAEs include primary adrenal insufficiency (0.7%...
Print Clinical researchPhase IIIBest Places to Work Merck & Co. MORE ON THIS TOPIC Neuropsychiatric disorders AbbVie Absorbs $3.5B Cost of Schizophrenia Flop January 13, 2025 · 2 min read · Tristan Manalac IPO M...
Adrenal insufficiency led to permanent discontinuation of KEYTRUDA in <0.1% (1) and withholding in 0.3% (8) of patients. All patients who were withheld reinitiated KEYTRUDA after symptom improvement. Hypophysitis KEYTRUDA can cause...