Using efonidipine, a dual L- and T-type CCB, it has been demonstrated that atrial electrical remodelling can be diminished in dogs. Furthermore, the T-type Ca2+ channel has recently been found in the pulmonary veins, contributing to the pulmonary vein pacemaker activity and triggered activity....
1.A method of preventing or treating coronavirus disease 2019 (COVID-19) in a subject in need thereof comprising administering a pharmaceutical composition comprising either a compound that binds specifically to Mpro of SARS-CoV-2 or a compound that binds specifically to RdRP of SARS-CoV-2,wher...
Heller J, Kramer HJ, Horacek C: The effect of kinin and prostaglandin inhibitors on the renal response to angiotensin converting enzyme inhibition: a micropuncture study in dogs. Eur J Physiol 1994, 427:219–224. Article CAS Google Scholar Zimmerman BG, Raich PC, Vavreck RJ, et al.: BK...
In a randomized clinical trial, high dose MPA administered for 6 months has been shown to induce resolution of the disease in 50% of the patients and a partial resolution in 13% of subjects compared to 12% and 6%, respectively, in patients who received placebo (Telimaa et al., Gynecol....