The pathogenesis and immune responses of HuNoV GII.4 infections have also been investigated in gnotobiotic calves. Studies in small animal models, such as mice, have also been conducted to investigate HuNoV infection. Humanized and nonhumanized BALB/c mice deficient in recombination activation gene ...
The dual capability of exosomes to promote immunity or to induce tolerance has prompted their clinical use as vehicles for vaccination against different human diseases. In the present study, the effect of allergen-specific exosomes from tolerized mice on the development of al...
Recombinant proteins, either alone or combined with adjuvant or with bacteria/recombinant virus as a delivery vehicles,58,59 have also been tested as vaccines in preclinical studies. There have been significant efforts in recent time to identify recombinant antigens that can protect against Leishmania...
TUNEL-positive cells were significantly increased due to CCl4administration, whereas both Fer-1 and bicyclol mitigated these cell death in the mice liver (Fig.2A, B). To further clarify the central role of ferroptosis in CCl4-injured mice, we used TEM to observe the mitochondrial morphology in ...
Exosomes are important intercellular communication vehicles that are very efficient in transferring nucleic acids, including miRNAs, between cells to elicit biological responses in recipient cells. It has recently been reported that autophagy can modulate human chondrocyte exosomes released in a GTPase-depend...
significantly more pronounced after IRI. Notably, old mice that underwent renal IRI (Fig.3a) had a 15-fold increase in cf-mt-DNA levels compared with young animals (Fig.3b). SystemicGAPDHwas absent from serum of old and young naive mice but became detectable in mice subjected to IRI (Fig...
Cornea transplantation holds the unique advantage in that gene therapy can be used to modify allografts ex vivo prior to transplantation. Many preclinical studies using local (and systemic) gene transfer have been performed to date and many different gene transfer vehicles (gene therapy vectors) and...
Finally, the vehicles were freeze-dried and kept in the refrigerator at 4 °C for future use. 2.4. Characterization of liposomes The nanoparticle sizes and zeta potentials of liposomes were measured through dynamic light scattering (DLS; Zetasizer Nano ZS90, Thermo Fisher Scientific, USA) at ...
on adult mice with multiple sclerosis concluded that the alcoholic extract of A. vera gel can reduce urea, uric acid, and creatinine levels and tissue modification of the kidney in such patients38. Prior to this study, no investigation has reported any prebiotic or probiotic holding the potential...
We purified, characterized, and quantified exosomes from ADSCs of mice. Our results show that exosomes from ADSCs protect against oxidative stress injury in vitro. Materials and methods Cell culture We purchased mouse ADSCs from Cyagen Biosciences Inc. (cat. MUBMD-01001). ADSCs were routinely ...