Hirama,N. Fritsch,J. C. Clardy.Synthesis of disodium prephenate and disodium epiprephenate. Stereochemistry of prephenic acid and an observation on the base-catalyzed rearrangement of prephenic acid to p-hydroxyphenyllactic acid. Journal of the American Chemical Society . 1979...
The inhibitions by tryptophan and phenylalanine are competitive with respect to prephenic acid, the substrate for the enzyme. Tyrosine, the end product of the third branch of the pathway, reverses the inhibition of prephenate dehydratase by tryptophan although it does not exhibit a strong allosteric...
Stereochemistry of prephenic acid and an observation on the base-catalyzed rearrangements of prephenic acid to p-hydroxyphenyllactic acid. J. Am. Chem. Soc. 101: pp. 7013-7018DANISHEFSKY, S., M. HIRAMA, N. FRITSCH, J. CLARDY. 1979. Synthesis of disodium prephenate and disodium epi...
Urea (1.0 M), 1 mM phosphate, 50% glycerol in phosphate or prephenic acid (substrate) did not release enzymatic activity from any of the gels. The gel-bound enzyme was found to have enhanced activity comparable to that of the methionine-activated soluble enzyme. The site and mode of the...
PrephenateOxidovanadium(IVInteractionsElectronic spectraElectronic paramagnetic resonanceThe interaction of the oxidovanadium(IV) cation with the sodium salt of prephenic acid was investigated by electron absorption and electronic paramagnetic resonance spectroscopies in aqueous solution at different pH values. ...
The maximum activity of the PdhE-1 protein occurred at pH 8.0 and 45 °C using prephenic acid as the substrate. The prephenate dehydrogenase had an apparent K m value of 0.87 mM, a V max value of 41.5 U/mg, a k cat value of 604.8/min and a k cat/K m value of 1....
Prephenic acid is a central biosynthetic intermediate between shikimic acid and various aromatic natural products. A new cyclohexandienone approach to the synthesis of disodium prephenate dimethyl acetal is described.: Current prophylaxis for infected tick bites consists of personal protective measures ...