251-259. The Hammett constant values are generally negative for electron donating groups (σp=−0.66 for NH2) and positive for electron withdrawing groups (σp=0.78 for a nitro group), σp indicating para substitution. Exemplary electron-withdrawing groups include nitro, ketone, aldehyde, ...
The present invention relates to processes for the synthesis of a crystalline polymorph of 10,10-Bis((2-fluoro-4-pyridinyl)methyl)-9(10H)-Anthracenone in high purity. The product is useful in the synthesis of pharmaceutical compounds for the reduction of cholinergic system dysfunction. Application...
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Another example is the human whole blood assay which is carried out according to a method of Patrignani et al. (P. Patrignani, M. R. Panana, A. Greco, O. Fusco, C. Natoli, S. Iacobelli et al.,J. Pharmacol. Exp. Ther.1994, 271, 1705-1710). For this, at least five test subj...