The present invention relates to processes for the synthesis of a crystalline polymorph of 10,10-Bis((2-fluoro-4-pyridinyl)methyl)-9(10H)-Anthracenone in high purity. The product is useful in the synthesis of pharmaceutical compounds for the reduction of cholinergic system dysfunction. Application...
Another example is the human whole blood assay which is carried out according to a method of Patrignani et al. (P. Patrignani, M. R. Panana, A. Greco, O. Fusco, C. Natoli, S. Iacobelli et al.,J. Pharmacol. Exp. Ther.1994, 271, 1705-1710). For this, at least five test subj...
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251-259. The Hammett constant values are generally negative for electron donating groups (σp=−0.66 for NH2) and positive for electron withdrawing groups (σp=0.78 for a nitro group), σp indicating para substitution. Exemplary electron-withdrawing groups include nitro, ketone, aldehyde, ...