Natural extracts are usually composed of hundreds to thousands of metabolites, whereby the bioactivity of natural extracts can be represented by synergism between several metabolites. However, isolating every single compound from a natural extract is not always possible due to the co...
Sensitization and elicitation in allergic contact dermatitis are complicated cellular and molecular processes [16], and the issue of skin irritation has been taken very seriously by perfume manufacturers and regulatory bodies. In 1999, the Scientific Committee on Consumer Safety (SCCS) of the European...