Adoptive cell transfer (ACT) using neoantigen-specific T cells is an effective immunotherapeutic strategy. However, the difficult isolation of neoantigen-specific T cells limits the clinical application of ACT. Here, we propose a method to prepare neoant
With this objective in mind, we have performed several series of experiments, the results of which prove to be exceptionally significant.METHODS AND RESULTS It was necessary, before such a study could be initiated, to prepare highly purified preparations of "secretin." This has been done by Ivy...
Before your surgery, you'll getanesthesiathrough an IV line that goes into a vein in your arm or hand. You might also breathe in gas through a mask. You should fall asleep within a couple of minutes. Once you're asleep, the doctor might put a tube through your mouth into your windpip...
For each chromatographic separation, equivalent amounts were loaded per lane of the Starting material (SM), the Wash #1 fraction (W#1), the Wash #2 fraction (W#2), and Eluate (E)) were separated by SDS-PAGE (6%; non-denaturing). The Eluate (E) from a chromatographic separation of cr...
the compositions of the subject invention can be used to treat or ameliorate the immuno-suppressive effects of chemotherapy and/or radiation therapy. In one embodiment, the composition of the subject invention is administered before, during, and/or after the administration of a chemotherapeutic agent...
Plasma frozen after overnight storage of blood is a satisfactory starting material for the preparation of factor VIII and factor IX concentrates.doi:10.1046/j.1537-2995.1978.18579036380.xJ. K. SmithPlasma Fractionation Laboratory and the Regional Blood Transfusion Centre, Churchill Hospital, Oxford, ...
The rate of bleeding complications requiring transfusion therapy due to the use of heparin also is approximately 7%. Moreover, even though delayed closures are significant, administration of heparin after termination of the procedures is of little value and can be detrimental. The widely used blood-...
This conventionally is accomplished by either insolubilizing the binding partner or analyte analogue before the assay procedure, as by adsorption to a water insoluble matrix or surface (Bennich et al., U.S. 3,720,760), by covalent coupling (for example using glutaraldehyde cross-linking), or ...
In addition anti-Rhesus D immunoglobulin can be used after mistransfusions of Rhesus positive blood to Rhesus negative recipients in order to prevent sensitization to the Rhesus D antigen. Further the invention relates to the application of these Fab fragments and antibodies as diagnostic reagents. H...
US5457181 * 1991年4月11日 1995年10月10日 Centre Regional De Transfusion Sanguine De Lille Preparation of a high-purity human factor IX concentrate and other plasmatic proteins and their therapeutic useUS5457181 * Apr 11, 1991 Oct 10, 1995 Centre Regional De Transfusion Sanguine De Lille ...