如果子痫发生在32周之前,被称为早期子痫,子痫也可能发生在产后。 Preeclampsia is a serious blood pressure disorder that can affect all of the organs in a woman’s body. A woman has preeclampsia when she has high blood pressure and other signs that her organ systems are not working normally. One...
Women with severe features of preeclampsia had a higher risk for adverse maternal outcomes compared to women without severe feature of preeclampsia. This finding was similar to a several other studies30,31,32. However, this finding was also lower than a study in Uganda in 2020 that found women...
112,113. Before miRNAs begin to circulate, they are first cleaved in the cytoplasm rendering them functional to operate as gene enhancers or silencers114. miRNAs are capable of binding with messenger RNA (mRNA) and inhibiting or enhancing the expression level of the mRNA after binding with...
To advance the field of perinatal molecular epidemiology, our goal was to develop an accessible and robust gene expression deconvolution reference for healthy placental villous tissue at term. We generated single-cell RNA-sequencing data with technical replicates for integration with existing cell type-s...
Abnormal trophoblast invasion is a hallmark of PE and is associated with compromised uteroplacental blood flow. Some studies suggest that lack of PP13 might contribute to endothelial dysfunction96,100, a central feature of PE. This dysfunction could be due to the direct effects of PP13 or ...
Out of them, 25 females were excluded.Results: As regarding body weight, there was a significant difference between the control group (79.9±6.36 kg) and preeclamptic without severe feature group (87.7±10.58 kg). The mean body weight in severe preeclampsia group was (91.5 ±14.73kg) which ...
Proteinuria is ideally determined by theevaluationof a 24-hour urine collection. However, current guidelines state that massive proteinuria is not considered a severe feature of preeclampsia. Reducedkidneyperfusion causes renal deterioration and damages glomerular endothelial cells allowing protein molecules to...
A recent experimental study removed the confounder of preterm births and exposed full-term rat pups newly born to pregnant dams with uteroplacental insufficiency, a feature of preeclampsia, to oxygen stresses similar in degree to those experienced by preterm infants who are at risk of severe ROP....
Diagnosis of PE with severe features was made with strict adherence to previously published guidelines by The Task Force on Hypertension in Pregnancy32. PE has mechanistically been classified into e-PE (<34 gestational weeks) and late onset PE (l-PE) (>34 gestational weeks), based on gestation...
Pregnant people are at higher risk for severe disease, and the chances of negative outcomes for mother and baby—such as preeclampsia, preterm birth, and stillbirth—increase with infection. Why Pregnant People Should Get COVID-19 Vaccines As Soon As Possible | Emily Barone | June 30, 2022 |...