severe featureObjective: To study the pregnancy outcomes of conservative treatment for preeclampsia with severe features. Methods: A retrospective study was conducted on pregnancies with preeclampsia with severe features at gestational age 23–34 weeks and that received conservative management a...
[136] have indicated that endothelial damage is a common feature of the pathophysiology of preeclampsia with severe features and severe infection with COVID-19, which could lead to multi-organ dysfunction. Furthermore, Leavitt et al. [136] have summarized three possible links between severe COVID...
Preeclampsia with severe features (sPE) 48 (14%) Superimposed PE (spPE) 27 (8%) Othera 112 (32%) Disposition after first triage visit: Admitted to hospital 217 (63%) Discharged home 129 (37%) Number of triage visits during index pregnancy 1 visit 212 (61%) 2 visits 91 (26%) ...
Intensive Care Unit UCG Uganda Clinical Guidelines WHO World Health Organization PEC Pre-eclampsia with severe feature PE Pre-eclampsia Supplementary Information The online version contains supplementary material available at https://doi. org/10.1186/s12884-024-06915...
Abnormal trophoblast invasion is a hallmark of PE and is associated with compromised uteroplacental blood flow. Some studies suggest that lack of PP13 might contribute to endothelial dysfunction96,100, a central feature of PE. This dysfunction could be due to the direct effects of PP13 or ...
Consistent with these observations, pregnant women with excessive inflammation and high cytokine levels, like those with severe infections, do not always develop preeclampsia. 4. A Unifying Hypothesis on Preeclampsia: Deranged Endothelin and Nitric Oxide Signaling The placenta is the most central organ ...
Gris, J. C. et al. Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial.Thromb. Haemost.106, 1053–1061 (2011). ...
Three models were trained for each feature set, l1 logistic regression, l2 logistic regression (sklearn LogisticRegression with class weight balanced, v1.1.1), and XGBoost (xgboost XGBClassifier, number of estimators = 10 and max depth = 5, v1.6.1). These models were then used to form a ...
Diagnosis of PE with severe features was made with strict adherence to previously published guidelines by The Task Force on Hypertension in Pregnancy32. PE has mechanistically been classified into e-PE (<34 gestational weeks) and late onset PE (l-PE) (>34 gestational weeks), based on gestation...
A total of 450 PDNAS samples (collected ≤16 weeks gestation, with confirmed clinical outcome) were part of the PE-training cohort, which included 135 cases of preeclampsia and 315 normal pregnancies (Fig.1a,b). We considered three feature sets defined as follows: ...