The predominant isozyme is inducible by either alanine stereoisomer and repressible by glucose. The gene dadX coding for its structure is located by the dadA gene determining the structure of D -amino acid dehydrogenase. The regulatory site for the expression of both genes, dadR , is located ...
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset progressive muscle disorder caused by a poly-alanine expansion mutation in the Poly(A) Binding Protein Nuclear 1 (PABPN1). The molecular mechanisms that regulate disease onset and progression are largely unknown. In order to identify molecula...
A large proportion of those metabolites mainly involved in amino acid metabolism, including tyrosine metabolism (3,4-dihydroxymandelaldehyde, 4-hydroxyphenylacetylglycine), histidine metabolism (1-methylhistidine, anserine) and beta-alanine metabolism (anserine). Alterations in amino acid metabolism were ...
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset progressive muscle disorder caused by a poly-alanine expansion mutation in the Poly(A) Binding Protein Nuclear 1 (PABPN1). The molecular mechanisms that regulate disease onset and progression are largely unknown. In order to identify molecula...