If dexamethasone is unavailable, use alternant glucocorticoids (eg, prednisone, methylprednisolone, or hydrocortisone) Prednisone 40 mg PO qDay for up to 10 days or discharge, whichever comes first; use in addition to standard of care Consider prednisone use as follows Supplement oxygen, but not ...
Thefluorinated corticosteroids, includingbetamethasoneanddexamethasone, transfer across theplacentaat much higher levels than prednisone ormethylprednisolone[97]. Therefore dexamethasone and betamethasone should be avoided in pregnancy unless the intention is to treat the fetus; these are the drugs of choice ...
the average area under the curve ratio (methylprednisolone/methylprednisone) was 9.3 These findings demonstrate that methylprednisone is a metabolite of methylprednisolone in the rat and suggest that the metabolic back-conversion of methylprednisone to methylprednisolone may be less than in other species....
(HSCT) for primary immunodeficiency, developed cardiac chamber hypertrophy (CCH) after receiving high-dose methylprednisolone or equal potency prednisone for graft versus host disease ( GVHD ) [ duration of treatment to reaction onset not stated ]; one infant also developed left ventricular outflow ...
The growth of knowledge in the field of the pharmacokinetics of prednisolone/prednisone has been slow for several reasons. First, convenient and specific m