daily for 3 days (depending on severity of the flare, then decreasing by 10 to 15 mg/day every 3 days until discontinuation). Alternatively, for relatively mild attacks of acute gout, amethylprednisolonesingle dose is sometimes used in clinical practice, but this is not an evidence-based ...
If dexamethasone is unavailable, use alternant glucocorticoids (eg, prednisone, methylprednisolone, or hydrocortisone) Prednisone 40 mg PO qDay for up to 10 days or discharge, whichever comes first; use in addition to standard of care Consider prednisone use as follows Supplement oxygen, but not ...
concentrations of prednisolone. Therefore, in order to compare pharmacokinetic results between different subjects, standardised doses had to be administered. The investigations performed so far have revealed that: (1) the dose-dependent pharmacokinetics partly explain the clinical observation that an alterna...
(HSCT) for primary immunodeficiency, developed cardiac chamber hypertrophy (CCH) after receiving high-dose methylprednisolone or equal potency prednisone for graft versus host disease ( GVHD ) [ duration of treatment to reaction onset not stated ]; one infant also developed left ventricular outflow ...
the average area under the curve ratio (methylprednisolone/methylprednisone) was 9.3 These findings demonstrate that methylprednisone is a metabolite of methylprednisolone in the rat and suggest that the metabolic back-conversion of methylprednisone to methylprednisolone may be less than in other species....