Extensively metabolized in liver; hydroxylated to active metabolite; conversion can be impaired in liver disease Metabolite: Prednisolone (active) Elimination Half-life: 2.6-3 hr Dialyzable: Hemodialysis, no Excretion: Urine (mainly) Administration Oral Administration Take with meal or snack High-dose...
concentrations of prednisolone. Therefore, in order to compare pharmacokinetic results between different subjects, standardised doses had to be administered. The investigations performed so far have revealed that: (1) the dose-dependent pharmacokinetics partly explain the clinical observation that an alterna...
The conversion of products of formula VII to products of formula VIII is carried out in the first place by the action of a halogenating reagent, preferably by bromination with the preferred reagent being pyridinium perbromide Py H+, Br3. The reaction is preferably done in the presence of a ...
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