Musculoskeletal: Osteonecrosis of femoral and humeral heads, Charcot-like arthropathy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures Neurologic: Arachnoiditis, convulsions, depression, emotional instability...
Post-marketing surveillance reports indicate that the risk of tendon rupture may be increased in patients receiving concomitant fluoroquinolones (e.g.,ciprofloxacin, levofloxacin) and corticosteroids, especially in the elderly. Tendon rupture can occur during or after treatment with quinolones. Hepatic Enzy...
Tendon rupture, particularly of the Achilles tendon Vertebral compression fractures Aseptic necrosis of femoral and humeral heads Pathologic fracture of long bones Gastrointestinal Peptic ulcer with possible perforation and hemorrhage Pancreatitis Abdominal distention Ulcerative esophagitis Dermatologic Impaired wound...
A guy goes to the doctor for acne. He’s given Accutane (isotretinoin). A possible side effect ofAccutane is Inflammatory Bowel Disease(IBD). To treat the IBD, he’s given Cipro (antibiotic) and Prednisone (corticosteroid).Cipro has been linked to tendon rupture. Reported, though rare, sid...
The elderly are especially at risk and tendon rupture may occur during or after treatment with fluoroquinolones. Combining aspirin, ibuprofen (Motrin) or other nonsteroidal anti-inflammatory agents (NSAIDS) with corticosteroids increases the risk of stomach related side effects like ulcers. Barbiturates...
(FDA MedWatch definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * requires intervention to prevent permanent impairment or damage An 80-year-old man experienced osteoporotic fractures and Achilles' tendon rupture while receiving ...
topical, ophthalmic, intra-articular, bursal, or intratendon administrationIncreased Susceptibility to InfectionGlucocorticoids, especially in large doses, increase susceptibility to and mask symptoms of infection.Infections with any pathogen, including viral, bacterial, fungal, protozoan, or helminthic infect...
Tendon rupture, particularly of the Achilles tendon Vertebral compression fractures Aseptic necrosis of femoral and humeral heads Pathologic fracture of long bones Gastrointestinal Peptic ulcer with possible perforation and hemorrhage Pancreatitis Abdominal distention ...
Levofloxacin/moxifloxacin/prednisoneThe article presents a case study of a 73-year-old man who developed spontaneous bilateral Achilles tendon ruptures after receiving prednisone, levofloxacin, and moxifloxacin treatment for chronic obstructive pulmonary disease (COPD).doi:10.1007/s40278-015-8030-9None...
Post-marketing surveillance reports indicate that the risk of tendon rupture may be increased in patients receiving concomitant fluoroquinolones (e.g.,ciprofloxacin, levofloxacin) and corticosteroids, especially in the elderly. Tendon rupture can occur during or after treatment with quinolones. ...