If dexamethasone is unavailable, use alternant glucocorticoids (eg, prednisone, methylprednisolone, or hydrocortisone) Prednisone 40 mg PO qDay for up to 10 days or discharge, whichever comes first; use in addition to standard of care Consider prednisone use as follows Supplement oxygen, but not ...
The growth of knowledge in the field of the pharmacokinetics of prednisolone/prednisone has been slow for several reasons. First, convenient and specific methods for measuring these steroids only became available with the development of high performance liquid Chromatographic methods. Secondly, prednisolone...
Thefluorinated corticosteroids, includingbetamethasoneanddexamethasone, transfer across theplacentaat much higher levels than prednisone ormethylprednisolone[97]. Therefore dexamethasone and betamethasone should be avoided in pregnancy unless the intention is to treat the fetus; these are the drugs of choice ...
Grade III or IV acute GVHD was treated with methylprednisolone 30 mg/kg/day for 3 days, decreased every 3 days to 20 mg/kg/day, 10 mg/kg/day, 5mg/kg/day, 3.75 mg/kg/day and 2 mg/kg/day. Methylprednisolone (or equal potency prednisone) was subsequently dec ... 展开 ...
250 ng/ml occurred within 5 min of methylprednisolone administration and the average area under the curve ratio (methylprednisolone/methylprednisone) was 9.3 These findings demonstrate that methylprednisone is a metabolite of methylprednisolone in the rat and suggest that the metabolic back-conversion of...