Prednisone for chronic active liver disease: pharmacokinetics, including conversion to prednisolone. Gastroenterology, 72, 910-913.Schalm SW, Summerskill WHJ, Go VLW: Prednisone for chronic active liver disease:
The investigations performed so far have revealed that: (1) the dose-dependent pharmacokinetics partly explain the clinical observation that an alternate-day regimen with prednisone yields fewer biological effects; (2) the interconversion of prednisone into prednisolone is not a limiting factor, even in...
(active drug) is preferred. There is evidence of poor conversion of prednisone to prednisolone or poor absorption of prednisone in cats, and prednisolone or another active drug (e.g., triamcinolone) should be used instead. There are several large animal doses cited (similar to prednisolone); ...
These differences may be due to decreased gastrointestinal absorption of prednisone vs. prednisolone, or to decreased hepatic conversion of prednisone to prednisolone in cats. These data indicate that oral prednisolone is the superior choice for cats. Funding: The Companion Animal Fund, Michigan State ...
Madsbad S, Bjettegaard B, Henriksen JH, Juhe E, Kehlet H. Impaired conversion of prednisone to prednisolone in pa- tients with liver cirrhosis. Gut 1980;21:52-6.Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis. Madsbad S,Bjerregaard B,Henriksen J H,Juhl E...
Effects of cimetidine and ranitidine on the conversion of prednisone to prednisolone. Clin Pharmacol Ther 1985; 37: 534–8Sirgo MA, Rocci Jr ML, Ferguson RK, et al. Effects of Cimetidine and ranitidine on the conversion of prednisone to prednisolone. Clin Pharmacol Ther 1985; 37(5): 534–8...
Jenkins JS, Sampson PA. Conversion of cortisone to cortisol and prednisone to prednisolone. Br Med J. 1967 Apr 22; 2 (5546):205–207.JENKINS, J.S. & SAMPSON, P.A. ( 1967 ). Conversion of cortisone to cortisol and prednisone to prednisolone . Br. med. J. , 2 , 205 – 207 ....