Results A total of 435 patients were referred for a COPD exacerbation warranting hospitalization; 107 patients were randomized to receive IV therapy, and 103 to receive oral therapy. Overall treatment failure within 90 days was similar, as followsIV prednisolone, 61.7%; oral prednisolone, 56.3% (...
Oral or IV Prednisolone in the Treatment of COPD Exacerbations: A Randomized, Controlled, Double-Blind Study: de Jong YP, Util SM, Grotjohan HP, et al. Chest 2007;132:1741–7 Author links open overlay panelMaria G.FrankMDShow more Share Cite...
On hospitalization, corticosteroids are generally administered IV. It has not been established whether oral administration is equally effective. We conducted a study to demonstrate that therapy with oral prednisolone was not inferior to therapy with IV prednisolone using a double-blind, double-dummy ...
Oral AdministrationAdminister orally as tablets, syrup, or oral solution.DosageDosage of prednisolone sodium phosphate is expressed in terms of prednisolone.After a satisfactory response is obtained, decrease dosage in small decrements to the lowest level that maintains an adequate clinical response, and...
Related to Prednisolone acetate:Moxifloxacin pred·nis·o·lone (prĕd-nĭs′ə-lōn′) n. A synthetic corticosteroid, C21H28O5, derived from cortisol and used as an anti-inflammatory, immunosuppressive, and antiallergic drug. [Blend ofprednisoneand-ol.] ...
Conclusion: Therapy with oral prednisolone is not inferior to IV treatment in the first 90 days after starting therapy. We suggest that the oral route is preferable in the treatment of COPD exacerbations. Trial registration: Clinicaltrials.gov Identifier: NCT00311961. (CHEST 2007; 132:1741–1747...
1 Oral prednisolone is approximately 70% bioavailable.2 Volume of distribution A 0.15mg/kg dose of prednisolone has a volume of distribution of 29.3L, while a 0.30mg/kg dose has a volume of distribution of 44.2L.1 Protein binding Prednisolone's protein binding is highly variable, ranging ...
Severe or life-threatening acute asthma (when oral corticosteroid taken for more than a few days) Children—1month–11years 2mg/kg once dailyOralBritish National FormularyMaximum dose 60mg, for up to 3days; treatment may be longer if necessary. For children aged 12–17years, or adults, the...
Prolonged use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses. The use of oral corticosteroids is not recommended in the treatment of optic neuritis...
Flo-Pred (prednisoloneacetate oral suspension) is asteroidused to treat many different conditions such as allergic disorders, skin conditions,ulcerative colitis,arthritis,lupus,psoriasis, or breathing disorders. What Are Side Effects of Flo-Pred?