The present invention relates generally to human genetics fields. Specifically, the present invention relates to the discoveries that some allele of A-T genes cause the neurological susceptibility of cancer, especially breast cancer. It is more particularly related to the germ line mutation in A-T ...
A new research paper titled "Determination of genetic predisposition to early breast cancer in women of Kazakh ethnicity" has been published inOncotarget. Breast cancer (BC) is the most common type of cancer among women in Kazakhstan. To date, little data are available on the spectrum of geneti...
Genetic predisposition to breast cancerdoi:10.1002/1097-0142(19920915)70:4+<1747::AID-CNCR2820701616>breast cancergenetic predispositionfamilial cancerinheritanceBreast cancer is the most common cancer among American women. Because metastatic breast cancer is an incurable disease, efforts to decrease ...
More specifically, the present invention relates to germline mutations in the A-T gene and their use in the diagnosis of predisposition to breast cancer. The invention further relates to somatic mutations in the A-T gene in human breast cancer and their use in the diagnosis and prognosis of ...
MRI screening of women with hereditary predisposition to breast cancer: diagnostic performance and survival analysis. Breast Cancer Res Treat (2014) 147:685-7. doi:10.1007/s10549-014-3097-1Tharmaratnam K, Hagen AI, Møller P (2014) MRI screening of women with hereditary predisposition to ...
to capture RNA transcripts produced from intronic and intergenic regions within 1.5-Mb intervals surrounding known breast cancer GWAS signals at the time of capture design (139/196 signals; Fig.1a; Additional file2: Table S3). Additional control sequences were added to the capture design to ...
Germline mutation in the RAD51B gene confers predisposition to breast cancer. BMC Cancer. 2013;13:484.Golmard, L., Caux-Moncoutier, V., Davy, G., Al Ageeli, E., Poirot, B., Tirapo, C., Michaux, D., Barbaroux, C., d'Enghien, C.D., Nicolas, A., et al. (2013). Germ-...
Introduction It has been shown in our previous work that breast asymmetry is related to several of the known risk factors for breast cancer, and that patients with diagnosed breast cancer have more breast volume asymmetry, as measured from mammograms, than age-matched healthy women. Methods In th...
Recent Advances in the Identification of Genetic and Biochemical Components of Breast Cancer PredispositionBreast cancerBreast cancer is one of the most common malignancies affecting women; thus, much effort has been put into understanding the genetics of predisposition to breast cancer as well as ...
[http://www.ncbi.nlm.nih.gov/pubmed/24687378] concluded that survival from breast cancer in very high risk women is better in screened versus unscreened women with or without a demonstrated genetic cause, and that BRCA2 mutation carriers may benefit from MRI screening in addition to ...