A study conducted by Adam Artigues reported the dysregulation of miRNA-30b-5p in breast cancer metastasis patients. This is another biomarker that can be detected in blood. The researchers first measured the levels of miRNA-30b-5p in tissue samples and then confirmed its potential as a biomarker...
‘Predictive’ and ‘prognostic’ markers are often used interchangeably in such studies, although they actually have clearly different definitions and implications. A ‘predictive’ marker describes the probability of response to a specific therapeutic agent or modalities, whereas a ‘prognostic’ marker ...
Before mass proteomic techniques, many individual proteins have been examined for their prognostic or predictive biomarker relevance in MM, one of which is programmed death-ligand 1 (sPD-L1), which when bound to its receptor PD-1 on T-cells promotes immune tolerance. Soluble PD-L1 in bone mar...
Biomarkers may be either prognostic or predictive in nature (Fig. 1). A prognostic biomarker provides insight into the overall disease outcome of a patient but does not predict the likelihood of benefit from a treatment. Predictive biomarkers, on the other hand, provide insight into the probabilit...
versus EP alone, with HRs of 0.88 (95% CI 0.66–1.19) in the IC < 1% subgroup and 0.53 (95% CI 0.31–0.90) in the IC ≥ 1% subgroup, indicating that PD-L1 expression could potentially function as a promising biomarker for assessing the effectiveness of combination therapy ...
S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure Heart failure is the most prevalent complication of acute myocardial infarction. Here, the authors show that circulating S100A8/A9 is a robust predictor and potentially causal medicator for heart...
. Serum crosslinked-N-terminal telopeptide of type I collagen (NTx) has prognostic implications for patients with initial prostate carcinoma (PCa): a pilot study.Clin. Chim. Acta, 316–318 (2014). Matin, F.. A Plasma Biomarker Panel of Four MicroRNAs for the Diagnosis of Prostate Cancer.(...
Sonia Molina-Pinelo, María D Pastor, Luis Paz-Ares. (2013) VeriStrat: a prognostic and/or predictive biomarker for advanced lung cancer patients?. Expert Review of Respiratory Medicine , 1-4 /Kim ES, Hirsh V, Mok T et al. Gefitinib versus docetaxel in previously treated non-small-cell ...
biomarker to guide the clinical care of gastric cancer patients and should be validated using large patient cohorts in a prospective manner. Similar content being viewed by others A universal molecular prognostic score for gastrointestinal tumors
We investigated the predictive and prognostic effects of VeriStrat, a serum or plasma-based assay, on response and survival in a subset of patients enrolled on the NCIC Clinical Trials Group, BR.21 phase III trial of erlotinib versus placebo in previously treated advanced non–small-cell lung ca...