A special structure neural network, which is named flexible neural tree (FNT), was then utilized to integrate such information for generating a novel lysine acetylation prediction system named LA+FNT. When comp
Thus, based on this competition resulting from acetylation at a SUMOylation site, this study also raised the question of whether other protein PTMs can compete with SUMOylation. Machine learning is a common method currently used to resolve SUMOylation sites16,18,19,20. This study applied the...
ATAC-seq, Assay for Transposase-Accessible Chromatin using sequencing; CMs, cardiomyocytes; CUT&RUN, Cleavage Under Targets & Release Using Nuclease; ENCODE, Encyclopedia of DNA Elements; H3K27ac, histone H3 Lysine 27 acetylation; GWAS, genome-wide association study, H3K4me3, histone H3 lysine 4 ...
Indeed Nε-acetylation on internal lysines is a reversible post-translational modification involved in several biological processes, such as transcription regulation [159], [161], protein expression and stability [153], [164], [165], [166], [167], DNA repair [162], apoptosis [160], [163]...
Acetylation is a crucial post-translational modification for histones, and plays a key role in gene expression regulation. Due to limited data and lack of a clear acetylation consensus sequence, a few researches have focused on prediction of lysine acety
Learning from published algorithms that generally focus on predicting the most detectable peptides we developed a tool that incorporates protein abundance into the peptide prediction algorithm with the aim to determine the detectability of every peptide within a protein. We tested our tool, “Peptide ...
Studying post-translational modifica- tions provide details for intricacies of protein function and response to various external or internal stimuli. Neddylation is a highly dynamic and reversible post- translational modification, in which NEDD8 protein is covalently attached to a target lysine residue....
Fig 1. The importance of acetylation of STAT3 (pdb:1BG1) and lysine acetylation equation. (A) Jak- STAT signaling pathway, including phosphorylation and acetylation. (B) The schematic diagramof HSE. An acetyl group (CH 3 CO-) fromAce-CoA replaces the hydrogen atomin the epsilon-amino grou...
SHI S P,QIU J D,SUN X Y,et al.PLMLA:Prediction of Lysine Methylation and Lysine Acetylation by Com- bining Multiple Features[J].Molecular Biosystems, 2012,8(5):1520-1527.Shi SP, Qiu JD, Sun XY, et al. PLMLA: prediction of lysine methylation and lysine acetylation by combining ...
the side chain of lysine (K) can undergo many types of PTM, called K-PTM, such as "acetylation", "crotonylation", "methylation" and "succinylation" and also responsible for occurring multiple PTM in the same lysine of a protein which leads to the requirement of multi-label PTM site identi...