The inapplicability of amino acid covariation methods to small protein families has limited their use for structural annotation of whole genomes. Recently, deep learning has shown promise in allowing accurate residue-residue contact prediction even for s
An interesting aspect of this study is that homoplasmic states are less prevalent in metastatic cancer cells than in other cancer cells. Because we used core metastases for the analyses, the possibility of the contamination of surrounding healthy tissues can be excluded. One of the explanations is...