GraphEC generally has a higher score, with over 82% of the proteins found by Foldseek56 showing a higher TM score compared to CLEAN. When comparing the number of enzymes whose maximum TM-scores exceeded various thresholds (Fig. 5A), GraphEC surpassed CLEAN by 158, 136, 128, and 128% ...
2d. Over the course of the iterations, 3 domains move from a TM-score below 0.5 to a TM-score above 0.5. The benefits of using distance constraints rather than contact constraints were also examined. DMPfold was run with 8 Å constraints for residue pairs with a cumulative likelihood ...
For example, protein structures with a resolution (or MolProbity score) of 1 Å or lower are considered very high quality, while values above 3 Å are considered to have significantly less accurate structure information. We assess structural quality metrics before and after AF2-prescribed energy...
polygenic risk scoreobesityOBJECTIVEObesity is a key predictor of type 2 diabetes (T2D). However, metabolic complications are not solely due to increased BMI. We hypothesized that differences between genetically predicted BMI and observed BMI (BMI-diff) could reflect deviation from individual se...
1). All generated models were structurally aligned to experimental models using TM-align to determine modelling precision. On a scale from 0 to 1, a TM-score of over 0.5 between two proteins implies that they have the same fold, while below 0.2 suggests a random alignment. Each RBM ...
Children in the AMRT + group showed significantly increased C-reaction protein, score of pediatric sequential organ failure assessment and pediatric risk of mortality of children and longer hospital stay and ICU stay in the AMRT + group compared to the AMRT+- group (P < 0.05). ...
In the 298 propensity score-matched pairs (a statistical matching technique that attempts to estimate the effect of treatment by accounting for the covariates that predict receiving the treatment), the CT+MR group was again associated with a significantly lower risk of HCC recurrence (HR 0.74, P...
Assessment of laryngeal view: percentage of glottic opening score vs Cormack and lehane grading. Can J Anaesth. 1999;46:987–90. Article CAS PubMed Google Scholar Serocki G, Bein B, Scholz J, Dörges V. Management of the predicted difficult airway: a comparison of conventional blade ...
To assess cluster purity, we followed a two-step approach. First, we calculated the average LDDT and TM score per cluster to assess the structural similarity. For this, we aligned the representative to the cluster members using the structurealign -e INF -a module in Foldseek and reported the...
The experiments show that a few metrics, such as distance precision, have a high correlation with the model accuracy measure TM-score (Pearson's correlation coefficient >0.7). In addition, the metrics are applied to rank the distance prediction groups in CASP14. The ranking by our metrics ...