The ADCS-PACC is the primary outcome measure for the first clinical trial in preclinical AD (ie, the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s study). Design, Setting, and Participants With the ADCS-PACC, we derive pilot estimates of amyloid-related decline using data from 2 ...
This kind of approach can be useful for more efficient drug development efforts in oncology through reduction of investment in expensive experimentation during the discovery and preclinical phases; and ultimately support the intended clinical trial design....
This article shows that aducanumab treatment was able to reduce plaque load in a small study of patients with AD and supported the progression of the drug to a phase III clinical trial. CAS PubMed Google Scholar Bohrmann, B. et al. Gantenerumab: a novel human anti-Abeta antibody ...
All the studies in this review are retrospective; some studies use propensity score matched analyses or retrospective matched longitudinal cohort analysis to improve study validity, but none of the studies resemble a randomized, controlled trial. Additionally, follow-up times are between 1 to 3.5 ...
Trial registration This study has been registered in ClinicalTrials.gov (NCT03370744, https://www.clinicaltrials.gov) in November 15, 2017.Introduction Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disorder, causing globally heavy healthcare burden [1]. Increasing eviden...
Throughout the study, the trial statisticians were blinded to the different treatments. They were not given direct access to the database and only received data from which any information regarding treatment allocation was removed (e.g. all treatment data, plasma concentrations…). The randomization...
Our preclinical PDX trial on a small cohort of lymphoma models under immune deficiency seemed to inform that CD47hi should be a positive predictor for HX009 efficacy. Since CD47 seemingly co-regulated with PD-L1/L2 (Fig. 3 and Table 2), these CD47hi also express higher levels of PD-L1/...
Presently, the acetylome encompasses nearly 40,000 unique protein acetylation sites, as classified in the PhosphoSitePlus database [7]. Regulation of protein functions by acetylation occurs in multiple ways: by affecting protein stability, activity, localization, and interaction with other proteins or ...
All clinical data have been provided in the paper in the form of figures, in the text or in Supplementary Information (including the clinical trial protocol, STROBE checklist and the statistical analysis plan). Additional requests for clinical data should be addressed to the corresponding author ...
The first study to be conducted through the CIBER-CLAP is a multicenter randomized controlled open-label blinded endpoint experimental trial testing the application of IPC in a pig model of AMI. All animal studies have been approved by the Comunidad de Madrid ethics committee, and CNIC’s institu...