In addition, this protocol will help to determine the effect sizes (ES) for primary and secondary outcomes according to several aspects of the FST study design. Search strategy, Screening annotation, Data management Publications reporting studies testing different classes of antidepressants in FST will...
Conclusion: Normothermic perfusion resulted in superior graft preservation and less reperfusion injury compared with the current static cold storage protocol. Surgical relevance Vascularized composite allotransplantation (VCA) represents more than a surgical challenge. Injury to the limb during donor surgery...
A Study protocol of the in vivo availability experiment and the evaluation of cardiac function and histological analysis; B Electrocardiogram monitoring of porcine MI model showed ST segment elevation Full size image The echocardiography results are shown in Fig. 7. The EF value of the animals decre...
a leading industry initiative in providing a reliable de-risk strategy. Drik has also developed expeditious procedures for protocol review, Institutional Animal Care and Use Committee (IACUC) meets regularly each year to monitor the care and use of research animals. Drik has comprehensive processes ...
All clinical data have been provided in the paper in the form of figures, in the text or in Supplementary Information (including the clinical trial protocol, STROBE checklist and the statistical analysis plan). Additional requests for clinical data should be addressed to the corresponding author ...
For library preparation, RNA quality and concentration was measured using the Fragment Analyzer from AATI (now Agilent) with the total RNA Standard Sensitivity protocol. The Sequencing library was prepared from 200 ng total RNA with the TruSeq® Stranded mRNA LT-Set B (RS-122-2102, Illumina...
Wild-type C57BL/6 mice were purchased from Taconic and all in vivo experiments were approved under an NIH Animal Care and Use Committee approved protocol. Vaccine PRGN-2012 is built on Precigen’s gorilla adenovector platform. The GC46 gorilla adenovector was identified and isolated from ...
Cell replacement therapy is a promising therapeutic option for dry age-related macular degeneration (AMD). In this study, we outline our design for scalable manufacture with appropriate quality gates and present in vivo data for establishing preclinical safety and efficacy of an induced pluripotent ...
A wide variety of 18F-labeled PSMA-targeting PET radiotracers have been developed, including [18F]AlF-PSMA-11. As there is only limited data on the comparison with other 18F-labeled PSMA PET tracers, a comparative preclinical study between [18F]AlF-PSMA-
particularly those mimicking human disease with an intact tumor immune microenvironment, are an invaluable tool to study cancer development and evaluate new therapeutic targets. Here, we discuss recent advances in LUSC preclinical models, with a focus on genetically engineered mouse models (GEMMs) and ...