aAt the preclinical stage of drug development, you must extensively test your product in the laboratory to ensure it will be safe for human administration. We understand that selecting a research and development partner to perform such testing is a complex decision and that the science, communicatio...
PsychoGenics a preclinical contract research organization (CRO) focused on drug discovery and development, with an emphasis in CNS research.
Another consideration when providing new treatment options is the use of combinations, which is not addressed in this review. We here summarize recent advances in the late preclinical or early clinical stage in the search for a potent macrofilaricide, including drugs against the nematode and ...
Client:A clinical stage biotech focusing on the discovery and development of the next generation ADC therapeutics to treat patients in cancer and autoimmune diseases. Study:Several ADCs are being evaluated in preclinical efficacy trials. Study Design:Different animal models of autoimmune diseases have be...
Drug Discovery Preclinical Drug Development A guidance prepared by From a 2004 NIH Summit Workshop: ”A major reason for the tremendous cost of drug development is the high rate of drug candidate failure during clinical testing. The withdrawal of drug candidates in late-stage testing has a signif...
New drugs in preclinical and early stage clinical development in the treatment of heart failureHeart failurenovel investigational drugsclinical trialsacute heart failurereduced ejection fractionpreserved ejection fractionHeart failure (HF) represents a major health problem because of its high prevalence, high...
For small molecule drugs, milligram quantities of research grade material are usually suitable for early stage in vivo efficacy and ADME studies, as well as small PK and dose range-finding studies (the latter may require gram quantities). When a molecular entity is selected, preformulation ...
A discrepancy between our expectations based on preclinical models and the results of clinical trials calls for a revision of our theoretical views and questions every stage of translation-from how we model the disease to how we run clinical trials. In the following sections, we will use some ...
The clinical-stage drug BTZ-043 accumulates in murine tuberculosis lesions and efficiently acts against Mycobacterium tuberculosis Therapy of tuberculosis is challenging, mainly due to complex structures of necrotic granulomas that often impair drug delivery. In this work, the authors show that the dru...
drug developmentis a very crucial stage of the pharmaceutical and biotechnology manufacturer as it is attributed to high costs at the various stages of drug development. Thus, one of the key factors linked to the last stage drug failure is due to inability of new drug candidates to meet human...