Preclinical data and mode of action of amorolfine. Clin Exp Dermatol. 1992; 17 (Suppl. 1): 8-12. http://dx.doi.org/10.1111/j.1365-2230.1992.tb00270.xPolak AM.Preclinical data and mode of action of amorolfine. Clinical and Experimental Dermatology . 1992...
SAN DIEGO, April 1, 2024 /PRNewswire/ -- Adcentrx Therapeutics ("Adcentrx"), a biotechnology company revolutionizing Antibody-Drug Conjugate (ADC) therapeutics for cancer and other life-threatening disease...
based on our unique capabilities targeting the chromatin regulatory system,” said Adrian Gottschalk, President and Chief Executive Officer of Foghorn. “We are excited to present new preclinical data supporting the potent activity of FHD-909, a potentially...
Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering: Expert Opinion on Biological Therapy: Vol 12... Preclinical and clinical data for the use of mesenchymal stem cells in articular cartilage tissue engineering. Expert Opin Biol Ther 2012;12...
If drug 'developability' becomes an obstacle for drug delivery based on these in vitro data and predictions at the early stages of drug discovery and development, options such as prodrug approaches could be explored to enhance drug 'developability', in addition to different formulation methods. ...
Dosimetry models using preclinical positron emission tomography (PET) data are commonly employed to predict the clinical radiological safety of novel radiotracers. However, unbiased clinical safety profiling remains difficult during the translational exe
but only in patients weighing less than 80 kg (thus requiring 40 mg TID in the higher weight range). In addition, prior clinical data suggested that there was an effect of weight on clearance and that a dose of 40 mg TID in patients weighing <80 kg would exceed a limit impose...
Preclinical data indicate that ZA may have direct antitumour activity, as has been demonstrated preclinically in both in vitro and in vivo experiments. The majority of preclinical studies showing antitumour effects have used high doses of ZA, making it difficult to translate these data to the ...
The objective of this study was to evaluate the performance of the Wajima allometry (Css-MRT) approach published in the literature, which is used to predict the human plasma concentration–time profiles from a scaling of preclinical species data. A diverse and blinded dataset of 108 compounds fro...
These non-clinical data are encouraging and provide a basis for the efficacy and safety of JS-001 in clinical trials. Keywords: monoclonal antibody; JS-001; programmed cell death 1; T cells; receptor occupancy; pharmacokinetics; anti-drug antibody Acta Pharmacologica Sinica (2017) 38: 710–718...