Opti- mizing the preclinical Alzheimer's cognitive composite with semantic processing: the PACC5. Alzheimers Dement (N Y) 2017;3:668-77.Papp KV, Rentz DM, Orlovsky I, Sperling RA, Mormino EC. Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5. ...
Versions of the Preclinical Alzheimer Cognitive Composite (PACC) and within cohort standardization models have been implemented in multiple observational and clinical trials. Harmonizing PACC data across studies, however, requires modern psychometric approaches to reflect the psychometric, testing, and ...
Donohue and coauthors demonstrate the feasibility of a cognitive composite outcome for clinically normal elderly participants with evidence of Alzheimer
A decline in episodic memory is one of the earliest cognitive characteristics of Alzheimer disease and memory tests are heavily featured in cognitive composite endpoints that are used to demonstrate treatment efficacy. Assessments of episodic memory can take many forms including free recall, associate le...
In the whole group, plasma p-tau181 was significantly associated with cognitive decline (as measured by the preclinical Alzheimer cognitive composite (PACC); P = 0.020), whereas p-tau231 was the only plasma biomarker with a significant interaction with Aβ status (as defined by CSF Aβ...
The preclinical Alzheimer cognitive composite: measuring amyloid- related decline. JAMA Neurol. 2014;71(8):961–70. 12. Farias S, Saito N, Harvey D, Aisen P, Petersen R. The validity of self-reported functional decline varies by disease severity. Neurology. 2012;78:P04.205– P04.205. 13....
This study aimed to examine the relationship between this plasma Aβ composite biomarker and cognitive function in cognitively normal older adults in two independent cohorts.doi:10.1002/alz.045884John Wiley & Sons, LtdAlzheimer's & Dementia
PACC5 preclinical Alzheimer's cognitive composite, version 5 47 72.21 (4.94) 29 14.79 (3.04) 512.97 (224.9) 69.35 (30.5) 0.059 (0.012) 29.21 (1.14) − 0.269 (0.683) 61.4% Yildirim et al. Alzheimer's Research & Therapy (2023) 15:43 Page 6 of 9 Table 3 Volumes of ...
Future research directions include the use of more sensitive (eg, the preclinical Alzheimer cognitive composite) or domain-specific (eg, episodic memory or executive functioning) cognitive tests, functional measures (eg, Clinical Dementia Rating Scale Sum of Boxes) or diagnostic conversion (eg, from ...
Next, we classified prodromal Alzheimer’s disease participants (n = 603, age = 72 ± 8, 43% female) according to the best matching subtype to their atrophy pattern, and we tested whether subtypes showed cognitive decline in specific domains. In all Alzheimer’s disease dementia datasets we ...