ADCs delivering PBD dimer payloads represent a novel mode of action in the ADC area. An important feature of the highly cytotoxic DNA interstrand cross-links produced by the PBD dimers is their persistence in cells. This contributes to their potency and also to their ability to affect slowly ...
BsADC Platform: Innovating How We Treat Cancers Common light chain mAbs targeting tumor-associated antigens are assembled into bispecific antibodies (BsAb) with a low mismatch rate and ideal physiochemical properties. This approach allows for simultaneous targeting of multiple tumor-driven proteins, offer...
SAN DIEGO, April 1, 2024 /PRNewswire/ -- Adcentrx Therapeutics ("Adcentrx"), a biotechnology company revolutionizing Antibody-Drug Conjugate (ADC) therapeutics for cancer and other life-threatening disease...
ADC Overcome Drug Resistance Discover Translational Biomarkers Progress Your IO Molecule Integrate Mouse Clinical Trials Technology Spotlight Ex VivoPatient Tissue Platform Highly translatable screening assay for evaluating monotherapy and combination drug responses in patient tumors with endogenous immune cell pop...
The field is also starting to consider ADC interactions with the immune system and potential synergistic therapeutic opportunities therein. In an indication of future directions for the field, antibody conjugates bearing non-cytotoxic small-molecule payloads are being developed to reduce side effects ...
ADC Overcome Drug Resistance Discover Translational Biomarkers Progress Your IO Molecule Integrate Mouse Clinical Trials Product Spotlight Biospecimens High-quality patient tissue samples that offer excellent quality and comprehensive clinical data LEARN MORE ...
(DAR) ratio of 4, demonstrated single digit nanomolar potency in eight different solid tumor indications. A proprietary Trop2 PH1 ADC (antibody-linker-toxin), had equal or better on-target potency than first-in-class (FIC) Trop2 ...
Requirement in target antigen selection is also the efficacy in trafficking ADC into tumor cells. The internalization process, also known as receptor-mediated endocytosis, is crucial to ensure ADC transport into intracellular compartments where the payload is released through proteolytic degradation of the...
Antibody-drug conjugates (ADC) selectively deliver a cytotoxic drug to cells expressing an accessible antigenic target. Here, we have appended monomethyl auristatin E (MMAE) to an antibody recognizing the SLC34A2 gene product NaPi2b, the type II sodium-phosphate cotransporter, which is highly expres...
2024. Data from the first presentation demonstrates the ability to direct antibodies and antibody-drug conjugates (ADCs) to rationally selected epitopes of interest on challenging disease-associated proteins. Data from the second presentation show how a...