BsADC Platform 200+ TAA targets Good developabilities Increased potency & reduced toxicity RenNano® Hu-VHH Platform Good permeability Small and good building blocks for bi-/multi-specific Ab, CAR-1 etc. RenTCR-mimic™ TCR-mimic Platform ...
BsADC Platform 200+ TAA targets Good developabilities Increased potency & reduced toxicity RenNano® Hu-VHH Platform Good permeability Small and good building blocks for bi-/multi-specific Ab, CAR-1 etc. RenTCR-mimic™ TCR-mimic Platform ...
ADCs delivering PBD dimer payloads represent a novel mode of action in the ADC area. An important feature of the highly cytotoxic DNA interstrand cross-links produced by the PBD dimers is their persistence in cells. This contributes to their potency and also to their ability to affect slowly ...
ADC Overcome Drug Resistance Discover Translational Biomarkers Progress Your IO Molecule Integrate Mouse Clinical Trials Unlock Deeper Insights With Multi-omics Quality Tissue Our biobank stands apart with ultra-short ischemia times, ensuring unmatched traceability and reliability. Each sample is enriched with...
Advance Your ADC Overcome Drug Resistance Discover Translational Biomarkers Progress Your IO Molecule Integrate Mouse Clinical Trials Unlock Deeper Insights With Multi-omics Quality Tissue Our biobank stands apart with ultra-short ischemia times, ensuring unmatched traceability and reliability. Each sa...
Client:A clinical stage biotech focusing on the discovery and development of the next generation ADC therapeutics to treat patients in cancer and autoimmune diseases. Study:Several ADCs are being evaluated in preclinical efficacy trials. Study Design:Different animal models of autoimmune diseases have be...
Requirement in target antigen selection is also the efficacy in trafficking ADC into tumor cells. The internalization process, also known as receptor-mediated endocytosis, is crucial to ensure ADC transport into intracellular compartments where the payload is released through proteolytic degradation of the...
ADC Overcome Drug Resistance Discover Translational Biomarkers Progress Your IO Molecule Integrate Mouse Clinical Trials Unlock Deeper Insights With Multi-omics Quality Tissue Our biobank stands apart with ultra-short ischemia times, ensuring unmatched traceability and reliability. Each sample is enriched with...
(DAR) ratio of 4, demonstrated single digit nanomolar potency in eight different solid tumor indications. A proprietary Trop2 PH1 ADC (antibody-linker-toxin), had equal or better on-target potency than first-in-class (FIC) Trop2 A...
Biosafety Level (BSL) 2 biosafety laboratory certificate Rapid scheduling and reporting (14 weeks for entire project) Expert team of study directors, pathologists and technicians Experience with variety of antibodies including monoclonal, bispecific, Antibody Drug Conjugate (ADC) and nano-antibody...