Preclinical Alzheimer's disease (AD) is a relatively recent concept describing an entity characterized by the presence of a pathophysiological biomarker signature characteristic for AD in the absence of specific clinical symptoms. There is rising interest in the scientific community to define such an ...
1 The pathophysiologic changes of AD involve loss of neurons, brain atrophy, extracellular deposition of β-amyloid (Aβ) plaques, and intracellular accumulation of neurofibrillary tangles.2,3 Unfortunately, the classic clinical symptoms of AD, including progressive memory loss and behavioral changes, ...
These premotor symptoms may persist in the motor phase. CSF indicates cerebrospinal fluid. Table 1. View LargeDownload Neuroimaging Biomarkers of Preclinical PD MethodBiomarkerValueSource SPECT DAT SPECT Helpful in diagnosis of preclinical PD, but not clear whether it changes with disease progression ...
adj Synonyms for preclinical adjof or relating to the early phases of a disease when accurate diagnosis is not possible because symptoms of the disease have not yet appeared Synonyms presymptomatic Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.Want...
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that can affect virtually any organ system, leading to a wide range of symptoms and complications. Understanding this complex disease is a challenge that many researchers have faced over the years. The introduction of animal models ...
INTRODUCTION Depressive symptoms are among early behavioral changes in Alzheimer's disease (AD); however, the relationship between neurodegeneration and depressive symptoms remains inconclusive. To better understand this relationship in preclinical AD, we examined hippocampal volume and depressive symptoms in ...
4210Accesses 222Citations 5Altmetric Metrics Abstract There is growing recognition that the pathophysiological process of Alzheimer disease (AD) begins many years prior to clinically obvious symptoms, and the concept of a presymptomatic or preclinical stage of AD is becoming more widely accepted. Advance...
Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early ...
Issue 1—the definition of the preclinical stage of AD The fact that the disease process starts many years before the development of symptoms and that effective interventions could be initiated at this time in the future, make the definition of the preclinical stage necessary. Conceptually, the de...
The preclinical stage of AD continuum is defined by the identification of AD biomarkers crossing the pathological threshold in cognitively unimpaired individuals. While neuropsychiatric symptoms (NPS) are non-cognitive symptoms that are increasingly recognized as early manifestations of AD, the associations ...