The biologic activity of defined IgE epitopes can be validatedinvivoin animal models or by measuring mediator release from engineered basophilic cell lines. Finally, gene-editing approaches using the Clustered Regularly Interspaced Short Palindromic Repeats technology to either remove allergen genes or ...
Genetically engineered mice (GEM) are the gold standard for cancer modeling. However, strict recapitulation of stepwise carcinogenesis from a single tumor-initiating epithelial cell among genetically intact cells in adults is not feasible with the currently available techniques using GEM. In previous ...
Based on the physiological anatomical structure and geometry of human meniscus, porous and mesh meniscus models with ranging pore diameter from 0.25 mm to 0.7 mm (porosity 20–60%) to reflect different mechanical strength was designed. The designed 3D model was printed using the patent-owned cryo...
作者: Shen Helen 摘要: Despite political challenges, engineered primates could be better disease models than mice.关键词: Animals Animals, Genetically Modified Haplorhini Humans Huntington Disease Disease Models, Animal Gene Targeting Genetic Engineering DOI: 10.1038/503014a 被引量: 12 ...
We chose heparan sulfate proteoglycans (HSPG), which are known to be overexpressed in colon cancer25, as the tumor target. Histone-like protein A (HlpA) has a high affinity for HSPG25. Therefore, we engineered bacteria to express HlpA on their surface, to form the active navigation module...
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We illustrate recent human heart modeling in electrophysiology, cardiac mechanics, and fluid dynamics and highlight clinically relevant applications of these models for drug development, pacing lead failure, heart failure, ventricular assist devices, edge-to-edge repair, and annuloplasty. With a view ...
Due to recent innovations in gene editing technology, great progress has been made in livestock breeding, with researchers rearing gene-edited pigs, cattle, sheep, and other livestock. Gene-editing technology involves knocking in, knocking out, deleting,
we systematically engineer multiple pgSIT systems inDrosophilawhich consistently give rise to 100% sterile males. Importantly, we demonstrate that pgSIT-generated sterile males are fit and competitive. Using mathematical models, we predict pgSIT will induce substantially greater population suppression than...
(c) Calculated energies and molecular models of the initial (IS), transition (TS) and final (FS) states of the reaction between debrominated phenyl residue and phenylacetylene. Ea and Er refer to the activation and reaction energies, respectively. Color code: dark gray for C, white for H ...