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MPro first autocleaves the polyproteins at a Gln/Ala and Gln/Ser junction, then cleaves most of the remaining proteins from the first two reading frames of the viral genome, including RdRp [232]. RdRp integrates with nsp7 and nsp8 to assemble into the polymerase holoenzyme. (b) ...
Additionally, impaired antigen presentation mechanisms contribute to psoriasis susceptibility, notably through genes like HLA-C and ERAP1, which influence the presentation of autoantigens to T cells, further triggering the immune system. Collectively, these intertwined biological pathways create the chronic...
Outcomes by tumor histology and KRAS mutation status after lung stereotactic body radiation therapy for early-stage non-small-cell lung cancer. Clin Lung Cancer. 2015;16(1):24–32. 121. Abazeed ME, Adams DJ, Hurov KE, Tamayo P, Creighton CJ, Sonkin D, Giacomelli AO, Du C, Fries DF,...
The focus on living creatures (e.g. insects) for use in AI relies on understanding of the biology of life and the body, rather than the brain, as the mechanism for automated intelligence [48,49]. 4. AI in medical image analysis In the past few decades, medical imaging became an ...