concerning the underlying biological logic of these new clinical trial designs. Therefore, we provide this comprehensive review of the discovery and development of basket, umbrella, and platform trials and their underlying logic from the perspective of precision medicine. Meanwhile, we discuss future dir...
paradigm shift in biomarker discovery and clinical trial design on the way to what is now called "biomarker-driven cancer medicine" or "precision medicine... PG Aftimos,B Philippe,A Ahmad - 《Discovery Medicine》 被引量: 26发表: 2014年 Precision medicine in oncology drug development: a pharma...
Based on the clinical observations from AMPECT and the underlying mechanism of action ofnab-sirolimus, the PRECISION 1 trial was designed to assess the safety and efficacy ofnab-sirolimus in a tumor-agnostic study of patients with advanced cancers harboringTSC1orTSC2inactivating alterations. ...
N-of-1 clinical trials (crossover experiments conducted in single individuals) may be ideal for determining individual treatment effects, potentially enhancing therapeutic precision. However, comprehensive data on how often n-of-1 trials affect treatment decisions is lacking. We performed this study to...
level information such as cancer type, metastatic status, treatment modality, and trial success was also manually curated. Fig. 1: Procedure for parameterizing survival curves starting with published figures. aKaplan–Meier survival curve and at-risk table obtained from clinical trial publication. ...
piscicultura, peces, antimicrobien, poisson (animal), antimicrobials, metodos de ensayo, fishes, enfermedades de los peces, fish diseases, propriete antimicrobienne, maladie des poissons, antimicrobianos, fish culture, therapeutique medicamenteuse, antimicrobial properties, methode d'essai, trial methods ...
The AACR Project GENIE is an international data-sharing consortium focused on generating an evidence base for precision cancer medicine by integrating clinical-grade cancer genomic data with clinical outcome data for tens of thousands of...
In oncology clinical trials, many patients spend their final months at a central clinical trial facility far from home for “mandatory” protocol visits/diagnostic testing. Studies suggest that the travel strain may be greatest among patients living in l
Such definitions can have important implications for access to and reimbursement for treatment, clinical trial design, and pricing, as therapies targeting those molecularly defined indications cannot receive orphan-drug status. Distinct capabilities needed to reach every person with a rare ...
R. In vivo gene editing works in humans: Results of a phase 1 clinical trial for TTR amyloidosis. Mol. Ther. 29, 2633–2634 (2021). CAS PubMed PubMed Central Google Scholar Doudna, J. A. & Charpentier, E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. ...