N. Ertekin-Taner, "Genetics of Alzheimer disease in the pre- and post-GWAS era," Alzheimer's Research and Therapy, vol. 2, no. 1, page 3, 2010.N.E. Taner.Genetics of Alzheimer disease in the pre- and post-GWAS era. Alzheimers Res Ther . 2010...
In wheat, a genome-wide association study (GWAS) and genomic prediction (GP) analysis were conducted for pre-harvest sprouting (PHS) tolerance and two of its related traits. For this purpose, an association panel of 190 accessions was phenotyped for PHS (using sprouting score), falling number...
This review provides a brief summary of the genetic studies in AD preceding the GWAS era, with the main focus on the findings from recent GWASs. Potential approaches that could provide further insight into the genetics of AD in the post-GWAS era are also discussed. 展开 关键词:...
LD hub and MR-base: online platforms for preforming LD score regression and Mendelian randomization analysis using GWAS summary data 来自 Semantic Scholar 喜欢 0 阅读量: 220 作者:Z Jie,P Haycock,G Hemani,B Elsworth,D Evans 摘要: Motivation: LD score regression is a reliable and efficient ...
Research Analysis Platform(简称RAP,地址:https://ukbiobank.dnanexus.com/landing)是UKB与AMS和DNAnexus合作推出的云计算平台,功能强大,是未来数据分析和计算的趋势。本次推送介绍如何在RAP系统中创建表型数据(Phenotype)并进行Pre-GWAS质量控制,为后续的GWAS分析做准备。需使用到RAP平台的JupyterLab功能(Spark Cluster...
Genetics of Alzheimer disease in the pre-GWAS era Early-onset familial Alzheimer disease Alzheimer disease (AD), the most common dementia, currently affects an estimated 35 million patients world-wide [1] and is characterized by extracellular accumulation of the amyloid β (Aβ) peptide in senile...
This review provides a brief summary of the genetic studies in AD preceding the GWAS era, with the main focus on the findings from recent GWASs. Potential approaches that could provide further insight into the genetics of AD in the post-GWAS era are also discussed. ...
Data pre-processing performed prior to a GWAS presents challenges in Hardy-Weinberg (H-W) estimation, genotyping and accounting for factors such as sample structure. Recent developments towards overcoming these challenges are presented: the likelihood ratio test for H-W estimation, sequencing for ...
A significant increase in the resistance level was observed (i.e. a positive response to selection) after the selection process, and 17 regions significantly associated with that response were identified using a GWAS approach. Those regions included known QTL as well as potentially novel regions ...
Integrating electronic health records and GWAS summary statistics to predict the progression of autoimmune diseases from preclinical stagesdoi:10.1038/s41467-024-55636-6Biological SciencesGeneticsAutoimmune diseases often exhibit a preclinical stage before diagnosis. Electronic health record (EHR) based-biobank...