tzinger complexBrainstemIn a previous study, we showed that in an in vitro en bloc preparation of newborn rats perfused with standard [K+] (6.2 mM) and high [K+] (11.2 mM) artificial cerebrospinal fluid (aCSF), nociceptin/orphanin FQ (N/OFQ) suppresses bursting of pre-...
tzinger complexVRC, ventral respiratory columnXII, hypoglossalOn postnatal days P10–P15 in rat medulla, neurotransmitter receptor subunit composition shifts toward a more mature phenotype. Since medullary GABAARs regulate cardiorespiratory function, abrupt alterations in GABAergic synaptic inhibition could ...
The preBötzinger (preBötC) complex has been suggested as the primary site where systemically administered selective serotonin agonists have been shown to reduce or prevent opioid-induced depression of breathing. However, this hypothesis has not been tested pharmacologically in vivo. This study ...