Pre-miR-21 was bound to the p-SMAD2/3–DICER complex in the mouse heart. • miR-21 overexpression is dependent on a p-SMAD2/3–DICER1 regulatory mechanism in cultured fibroblasts. • DICER1 levels correlated with TGF-β1, SMAD2 and SMAD3 in the LV from AS patients. ...
MiR-21-5p knocked down significantly abrogated the cancer-promoting and macrophage M2 polarizing effects of H-EV treatment. H-EV treatment downregulated PTEN, PDCD4 and RECK gene expression largely through miR-21-5p. Overexpressing PTEN, PDCD4 and RECK in A549 cells significantly reduced the miR-...
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MiR-21-5p knocked down significantly abrogated the cancer-promoting and macrophage M2 polarizing effects of H-EV treatment. H-EV treatment downregulated PTEN, PDCD4 and RECK gene expression largely through miR-21-5p. Overexpressing PTEN, PDCD4 and RECK in A549 cells significantly reduced the miR-...