单细胞分析pre-B 型急性淋巴细胞白血病的骨髓微环境 文章信息 文章题目:The bone marrow microenvironment of pre‑B acute lymphoblastic leukemia at single‑cell resolution日期:2020年11月 期刊:Scientific reports 数据:GSE148115 链接:https://www.nature.com/articles/s41598-020-76157-4#article-info 摘要:...
骨髓微环境 (bone marrow microenvironment,BMM) 在白血病进展中起关键作用,但其在pre-B 细胞急性淋巴细胞白血病 (B-ALL)(儿童最常见的癌症)中的分子复杂性仍知之甚少。为了进一步了解,本文使用单细胞 RNA 测序来表征 B-ALL 进展过程中鼠 BMM 的变化。发现pre-B 细胞在疾病的早期阶段受影响最大,这与受 AP1 转...
Pre-B cell leukemia transcription factor (PBX) proteins are important mediators for retinoic acid-dependent endodermal and neuronal differentiation of mouse embryonal carcinoma P19 cells. J Biol Chem. 2004; 279:16263-16271. [PubMed: 14742427]...
Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. Hum Mol Genet. 2009; 18 (4):679–687. doi: 10.1093/hmg/ddn397. [ Cross Ref ]Cheung CL, Chan BY, Chan V, Ikegawa S, Kou I, Ngai H, Smith D, Luk KD, ...
The microenvironments of leukemia and cancer are critical for multiple stages of malignancies, and they are an attractive therapeutic target. While skeletal abnormalities are commonly seen in children with acute lymphoblastic leukemia (ALL) prior to init
acute lymphoblastic leukemiaThis case provides evidence for a phenotypic switch from a characteristic T-ALL into a typical pre-B ALL. A 17 years old boy presented with massive hepatosplenomegaly and a mediastinal mass. The blasts were characterized as L2 type according to the French, American and...
(FISH) tested specific genotypes and copy number aberrations of the locus in 365 children with AL.Results Specific subtypes were identified in 175 patients with B-cell precursor acute lymphoblastic leukemia (Pre-B ALL) and 54 patients with acute myeloid leukemia(AML).Among PreB ALL cases,high ...
Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complet... Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease ...
Kokkaliaris bMichael D. Milsom cRoss L. Levine dRavindra Majeti eExperimental HematologyS. M. Sykes, K. D. Kokkaliaris, M. D. Milsom, R. L. Levine, and R. Majeti, "Clonal evolution of preleukemic hematopoietic stem cells in acute myeloid leukemia," Experimental Hematology, vol. 43,...
(A) Nonsense/missense, frameshift, and in-frame mutations or insertions/deletions (indels) (n = 104) detected in 38 mice with leukemia where sufficient material was available (out of 50 leukemic mice). Mice are arranged in columns, genes labeled and grouped along rows. (B) Pie charts depic...