c, d Heatmaps of k-means clusters and average tag density plots showing H3K4me3, H3K27me3, and H2AK119ub enrichment at promoter region (TSS ± 2 kb) in P1 oocytes. Clusters 2–4 differed in H3K4me3 localization (Cluster 2: H3K4me3 accumulation on 3'-side of transcription start sites ...
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Interestingly, the oj5 allele isolated in this screen as the cause of central spindle defects has been shown to be an R83W mutation35, which lies within the CYK-4-binding region of SPD-1 defined above. We tested whether this mutation affected the SPD-1–CYK-4 interaction and found that ...
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